Global IT company Digital Realty opened it first Australian outlet in Erskine Park on Thursday.
"This brings 250 jobs to western Sydney," said Digital Realty's Asia Pacific regional head Kris Kumar.
"We have 20 staff working full-time and our customers will be bringing the extra jobs."
The new facility, Digital Erskine Park, occupies 8020 square metres in Templar Road.
Mr Kumar said the company chose Erskine Park because its business park and transport links provided good access for customers. He also said the national broadband network's rollout in Penrith provided a better IT connection.
Premier Barry O'Farrell said the move was "a clear vote of confidence in the economy of western Sydney".
"An estimated 250 jobs created by this investment is great news for people in Sydney's west who want to work closer to where they live," Mr O'Farrell said.
The Australian Breastfeeding Association (ABA) has called for full support for all mothers feeding their babies in public.
"Seeing mothers breastfeed their babies is an important step to breastfeeding success", said ABA's spokeswoman, Jessica Leonard.
"Breastfeeding mothers should feed their babies however they feel comfortable, and not feel any pressure to meet other people's expectations of discretion.
"Mothers breastfeeding in public are helping the next generation of Australians to learn that breastfeeding is normal."
New mothers are encouraged to join the association. Details: www.breastfeeding.asn.au.